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Autoinflammatory Disorders

What Are Autoinflammatory Disorders?

These are defined as conditions caused by an exaggerated innate immune system response in episodes of spontaneous inflammation affecting multiple organs.

Autoinflammatory diseases are caused by genetic mutations in molecules that are involved in regulating the immune system’s response which is the defense system that normally recognizes and acts against infectious agents and other danger signals produced by our bodies. When the immune system doesn’t work properly, this system can cause harm. Immune cells can mistake your body’s own cells as invaders and attack them.

Autoinflammatory diseases are different from autoimmune diseases. However, autoimmune and autoinflammatory diseases share common characteristics in that both groups of disorders result from the immune system attacking the body’s own tissues, and also result in increased inflammation.

Autoinflammatory diseases are not contagious and they are not infectious diseases. When patients are having flares of their disease symptoms they cannot infect anyone.

The autoinflammatory diseases have unique dermatological presentations that can be a clue to diagnosis. Dr. Kathleen Smith at Dermatology Specialists of Atlanta has been trained and is experienced in diagnosing and treating auto inflammatory diseases.

Syndrome Classifications

  • Familial Mediterranean fever (FMF)
  • Tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS)
  • Hyper-IqD syndrome (HIDS).
  • CAPS
  • Blau

Dermatological Manifestations

When autoinflammatory disease flares they follow a characteristic pattern of intense episodes of inflammation each time that they occur, such as fever, rash, non-infectious conjunctivitis, vomiting, and diarrhea.

Dr. Kathleen Smith has done extensive study of autoinflammatory disorders and is able to diagnosis and treat these syndromes at Dermatology Specialists of Atlanta in Decatur, GA.

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